膜蛋白-TRPA1 Antibody

Datasheet

Description

Receptor-activated non-selective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function. Shows 8-fold preference for divalent over monovalent cations. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of irritants, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Is activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner, whereas mechanisms of non-electrophilic ligands are not well determined. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).


Uniport

Q75762


Alternative Names

ANKTM 1; ANKTM1; Ankyrin-like with transmembrane domains protein 1; Transformation sensitive protein p120; Transformation-sensitive protein p120; Transient receptor potential cation channel subfamily A member 1; TRPA 1; Trpa1; TRPA1_HUMAN;



Specificity

TRPA 1 Antibody detects endogenous levels of total TRPA 1.


Reactivity

Mouse, Rat


Source

Mouse

Mol Weight

128kD;


Storage

Store at -20 °C. Stable for 12 months from date of receipt.

Application

WB 1:1000-1:2000;IHC/IF 1:100-1:1000; IP 1:50-1:100;





M077162

货号 规格 价格(¥)
订购咨询 orders@ab-mart.com
技术支持 service3@ab-mart.com

订货热线 4006-123-828

经销商名录:点击查看


banner-500.jpg

艾比玛特医药科技(上海)有限公司
上海市徐汇区桂平路333号聚科生物园区1号楼1-3层

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13162127138

技术支持:13162477137

总机:021-34695901


wx.png

      微信客服

邮箱:market@ab-mart.com

总机:021-34695901

热线:13166434152 

订购专线:4006-123-828

wx.png

微信客服

沪ICP备17056956号-2    艾比玛特医药科技(上海)有限公司