兔单抗-alpha smooth muscle Actin Antibody

Datasheet

UniProt

P62736

UniProt _link

http://www.uniprot.org/uniprot/P62736

Mol Weight

42kDa

Isotype

Rabbit IgG

Alternative Names

Actin, aortic smooth muscle, Alpha-actin-2, Cell growth-inhibiting gene 46 protein, ACTA2, ACTSA, ACTVS, GIG46

Application

Reactivity

Human Mouse Rat

Dilution

WB 1:1000~1:10000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:20

Purification

Affinity-chromatography

Specificity

alpha smooth muscle Actin Antibody detects endogenous levels of total alpha smooth muscle Actin

Immunogen

A synthesized peptide derived from human alpha smooth muscle Actin

Description

Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.

Storage Condition and Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

T51132

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