P62736
http://www.uniprot.org/uniprot/P62736
42kDa
Rabbit IgG
Actin, aortic smooth muscle, Alpha-actin-2, Cell growth-inhibiting gene 46 protein, ACTA2, ACTSA, ACTVS, GIG46
Human Mouse Rat
WB 1:1000~1:10000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:20
Affinity-chromatography
alpha smooth muscle Actin Antibody detects endogenous levels of total alpha smooth muscle Actin
A synthesized peptide derived from human alpha smooth muscle Actin
Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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