兔单抗-RYK Antibody

Datasheet

UniProt

P34925

UniProt _link

http://www.uniprot.org/uniprot/P34925

Mol Weight

72kDa

Isotype

Rabbit IgG

Alternative Names

ERK 3; JTK5; JTK5A; Ryk; RYK1; Vik;

Application

Reactivity

Human

Dilution

WB 1:1000~1:5000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50 FC 1:50

Purification

Affinity-chromatography

Specificity

RYK Antibody detects endogenous levels of total RYK

Immunogen

A synthesized peptide derived from human RYK

Description

May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

Storage Condition and Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

T58517

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