兔单抗-PAG Antibody

Datasheet

Description

Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins.

Uniprot

Q9NWQ8

Alternative Names

CBP; Csk binding protein; PAG; PAG1;

Reactivity

Human Mouse Rat

Source/Isotype

Rabbit

Application

Mol Weight

80kDa

Storage Condition

Store at -20 °C. Stable for 12 months from date of receipt.

Application

WB 1:500~1:2000 IHC 1:50~1:200 IP 1:50 FC 1:100

Western blot analysis of PAG expression in Raji cell lysate.

T58795

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