分子量

318.37

储存条件

3年-20°C 粉状
2年-80°C 溶于溶剂

化学式

C??H??N?O

CAS号

453097-13-6

别名

N/A

化学名

3-Methyl-1-(6-methyl-1H-benzimidazol-2-yl)-4-(phenylmethyl)-1H-pyrazol-5-ol

Solubility (25°C) *

体外

DMSO

 ≥ 34 mg/mL (106.79 mM)

Ethanol

Water

< 0.1 mg/mL (insoluble)

体内（现配现用）

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

浓度 / 溶剂体积 / 质量

1 mg

5 mg

10 mg

1 mM

3.1410 mL

15.7050 mL

31.4100 mL

5 mM

0.6282 mL

3.1410 mL

6.2820 mL

10 mM

0.3141 mL

1.5705 mL

3.1410 mL

产品描述

HUHS015 是一种高效的 PCA-1/ALKBH3 抑制剂，对 PCA-1 作用的 IC50 值为 0.67 μM。

靶点/IC50

PCA-1, IC50: 0.67 μM

体外研究

HUHS015 significantly suppresses the growth of DU145 cells, which are human hormone-independent prostate cancer cells.

体内研究

HUHS015 potently suppresses the growth of DU145 cells in a mouse xenograft model.
HUHS015 displays 7.2% bioavailability (BA) in rats after oral administration.