Histone demethylase that specifically demethylates "Lys-9" and "Lys-36" residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 "Lys-4", H3 "Lys-27" nor H4 "Lys-20". Demethylates trimethylated H3 "Lys-9" and H3 "Lys-36" residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

bA146B14.1; GASC 1 protein; GASC-1 protein; GASC1; Gene amplified in squamous cell carcinoma 1 protein; JHDM3C; JmjC domain containing histone demethylation protein 3C; JmjC domain-containing histone demethylation protein 3C; JMJD2C; Jumonji domain containing 2C; Jumonji domain containing protein 2C; Jumonji domain-containing protein 2C; Kdm4c; KDM4C_HUMAN; Lysine (K) specific demethylase 4C; Lysine demethylase 4C; Lysine-specific demethylase 4C; TDRD14C; Tudor domain containing 14C;

Q9H3R0

116KD

Mouse

Human, Mouse, Rat

WB 1:500-1:2000, IHC 1:50-1:200; IP 1:50-1:100

Store at -20 °C. Stable for 12 months from date of receipt.