Histone demethylase that specifically demethylates "Lys-4" of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 "Lys-9", H3 "Lys-27", H3 "Lys-36", H3 "Lys-79" or H4 "Lys-20". Demethylates trimethylated and dimethylated but not monomethylated H3 "Lys-4". Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).

DXS1272E; Histone demethylase JARID1C; JARID1C; JmjC domain containing protein SMCX; Jumonji AT rich interactive domain 1C; Jumonji, AT rich interactive domain 1C (RBP2 like); Jumonji/ARID domain-containing protein 1C; KDM5C; KDM5C_HUMAN; Lysine (K) specific demethylase 5C; Lysine-specific demethylase 5C; MRX13; MRXJ; MRXSCJ; MRXSJ; Protein SmcX; Protein Xe169; rbp2 like protein; Selected cDNA on X; SMCX; Smcx homolog X chromosome; SmcX protein; Smcy homolog X linked; XE169; Xe169 protein;

P41229

172KD

Mouse

Human, Mouse, Rat

WB 1:500-1:2000, IHC 1:50-1:200; IP 1:50-1:100

Store at -20 °C. Stable for 12 months from date of receipt.