FTO, also known as Fatso or KIAA1752, is a 505 amino acid protein that has an
N-terminal nuclear localization signal. Expressed in a variety of tissues, with
highest levels present in brain and pancreatic tissue, Fatso exists as four
alternatively spliced isoforms, once of which is associated with a
predisposition to childhood and adult obesity. Due to its involvement in the
development of obesity, Fatso is associated with an increased BMI and may be
involved in the pathogenesis of type 2 diabetes. The gene encoding Fatso
maps to human chromosome 16, which encodes over 900 genes and comprises
nearly 3% of the human genome. The GAN gene is located on chromosome 16
and, with mutation, may lead to giant axonal neuropathy, a nervous system
disorder characterized by increasing malfunction with growth. The rare
disorder Rubinstein-Taybi syndrome is also associated with chromosome 16,
as is Crohn’s disease, which is a gastrointestinal inflammatory condition.

1. Peters, T., et al. 1999. Cloning of Fatso (FTO), a novel gene deleted by the
Fused toes (Ft) mouse mutation. Mamm. Genome 10: 983-986.
2. Pascoe, L., et al. 2007. Common variants of the novel type 2 diabetes genes
CDKAL1 and HHEX/IDE are associated with decreased pancreatic -cell
function. Diabetes 56: 3101-3104.
3. Field, S.F., et al. 2007. Analysis of the obesity gene FTO in 14,803 type 1
diabetes cases and controls. Diabetologia 50: 2218-2220.
4. Dina, C., et al. 2007. Variation in FTO contributes to childhood obesity and
severe adult obesity. Nat. Genet. 39: 724-726.

FTO (2F8) is a mouse monoclonal antibody raised against amino acids 189-505
of FTO of human origin.

FTOmonoclonal antibody detects endogenous levels of FTO protein.

Store at -20°C. Stable for one year from the date of shipment.

Fatso, KIAA1752

H, (Cross-reactivity in other species is undetermined.)

Mouse IgG

#M20002 Myc-Tag (19C2) Mouse mAb
#M20003 HA-Tag (26D11) Mouse mAb
#M20004 GFP-Tag (7G9) Mouse mAb
#M20007 GST-Tag (12G8) Mouse mAb
#M20008 DYDDDDDK-Tag (3B9) Mouse mAb (Binds to same epitope as
Sigma’s Anti-FLAG M2 Antibody)
#M20012 Anti-Myc-Tag Mouse mAb (Agarose Conjugated)
#M20013 Anti-HA-Tag Mouse mAb (Agarose Conjugated)
#M20018 Anti-DYKDDDDK-Tag Mouse mAb (Agarose Conjugated) (Binds to
same epitope as Sigma’s Anti-FLAG M2 Antibody)