The most prominent clinical syndrome associated with a disordered hypersecretion of Calcitonin (CT) is medullary carcinoma of the thyroid (MTC). MTC is a tumor of the Calcitonin producing C-cells of the thyroid gland. Although MTC is rare, comprising 5 - 10% of all thyroid cancer, it is often fatal. Further, it leant itself to be diagnosed early by serum Calcitonin and total cure for early sub-clinical disease is possible. Neoplastic disorders of other neuroendocrine cells can also elevate Calcitonin. The best example is small cell lung cancer. Other tumors such as carcinoids and islet cell tumors of the pancreas can also result in elevated serum Calcitonin. Increases in serum Calcitonin has also been noted in both acute and chronic renal failure, hypercalciuria and hypercalcemia.
Calcitonin
Calcitonin, CT
P01258
This Abmart monoclonal antibody is produced by immunizing mice with a Synthetic peptide corresponding to the amino acids 16-32 of human Calcitonin, conjugated to a high molecular weight carrier
Mouse IgG2a
Human
ELISA 1: 50000--1:1000OOO
Stored at -20°C or below until use. Avoid repeated freezing and thawing cycles.
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。
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