c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock. They also play a role in T cell differentiation and the cellular apoptosis pathway. Activation occurs through a dual phosphorylation of threonine (Thr) and tyrosine (Tyr) residues within a Thr-Pro-Tyr motif located in kinase subdomain VIII. Activation is carried out by two MAP kinase kinases, MKK4 and MKK7.

This Abmart monoclonal antibody is produced by immunizing animals with a polypeptide (Abmart SEAL mAb technology) corresponding to p-JNK1/2/3 (Thr183+Tyr185) protein.

p-JNK1/2/3 (Thr183+Tyr185)

P45983/P45984/P53779

MAP kinase 8,MAPK 8,JNK-46,SAPK1c,JNK1,MAP kinase 9,MAPK 9,JNK-55,JNK2,MAP kinase 10,MAPK 10,MAP kinase p49 3F12,JNK3

WB 1:500-1:2000

46,54kDa

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Human Mouse Rat

Rabbit IgG