信号通路Signaling-Beta-Catenin (44C6) mAb

Datasheet

Background

The catenins, α,? and y, are proteins which bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. α-catenin was initially  described as an E-cadherin
associated protein, and since has been shown to associate with other members of the cadherin family, such as N- cadherin and P-cadherin. ?-catenin associates with the cytoplasmic portion of  E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. ?-catenin has also been found in complexes with the tumor suppressor  protein  APC. y-catenin, also known as plakoglobin, is a protein that binds with α-catenin and N-cadherin. It has been shown that the
transmembrane phosphatase PTPμ associates with catenin/cadherin complexes and may regulate complex signaling.

Uniport

P35222 

Source

This Abmart monoclonal antibody is produced by immunizing mice with a synthetic  peptide (KLH-coupled) corresponding to carboxy-terminal  residues of human ?-catenin.

Specificity

?-Catenin (44C6) Mouse  mAb detects  endogenous  levels of total  ?-catenin protein.

Storage

Store at -20°C, stable for one year from the date of shipment.

Application

Mol Weight

92kDa

Reactivity

Human, Mouse, Rat

Isotype

  1. Mouse IgG1

Secondary Antibodies

  1. 1. Centrifuge to settle the lyophilized antibody to the bottom of the vial.
    Reconstitute using 100 μl Antibody Dilution Buffer.

  2. 2. Use an anti-MOUSE secondary antibody to detect the 44C6 antibody.


Recommanded Dilutions

Western blotting                    1:1000
Immunofluorescence           1:200
Immunohistochemistry        1:200

*For Western blots, incubate membrane with diluted antibody in 5% w/v non-fat dry milk,  1× TBS, 0.05% Tween-20  at 4°C with gentle shaking, overnight.


Companion products

#M21001 Goat Anti-Mouse  IgG-HRP

M24002

货号 规格 价格(¥)
M24002M 100μl 以上产品均有现货供应
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