信号通路Signaling-DCTN1 mAb

Datasheet

Background

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB which is also known as distal spinal and bulbar muscular atrophy.

Source

This Abmart monoclonal antibody is produced by immunizing mice with a polypeptide (Abmart SEAL mAb technology) corresponding to DCTN1 protein.

Alternative Names

DCTN1

Uniport

Q14203

Alternative Names

150 kDa dynein-associated polypeptide; DAP-150; DCTN1; DP-150; dynactin 1; dynactin 1 (p150, Glued (Drosophila) homolog); dynactin 1 (p150, glued homolog, Drosophila); dynactin 1, retrograde axonal transport; Dynactin subunit 1; HMN7B; OTTHUMP00000202491; P135; p150, Glued (Drosophila) homolog; p150, Glued homolog; p150-glued

Application

Recommanded Dilutions

Western blotting 1:1000-1:5000

Predicted Mol Weight

136

Storage

Store at -20°C, stable for one year from the date of shipment.

Reactivity

Human

Isotype

Mouse IgG

M25406

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