信号通路Signaling-PDHA1 mAb

Datasheet

Background

The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO, and provides the primary link between glycolysis and the tricarboxylic acid  cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase , dihydrolipoamide acetyltransferase and lipoamide dehydrogenase. The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Source

This Abmart monoclonal antibody is produced by immunizing mice with a polypeptide (Abmart SEAL mAb technology) corresponding to ODPA protein.

Alternative Names

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Uniport

P08559

Alternative Names

mitochondrial; PDHA1; pdha1a; pdha1b; PHE1A; pyruvate dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase E1 alpha 1; Pyruvate dehydrogenase E1 component subunit alpha; somatic form

Application

Recommanded Dilutions

Western blotting        1:1000-1:5000                     

Immunoprecipitation     10 tests                

FACS                    1:100-1:200                          


Predicted Mol Weight

43 KDa

Storage

Store at -20°C, stable for one year from the date of shipment.

Reactivity

Human

Isotype

Mouse IgG

M25410

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