病理Pathologic Biomarker-Homeobox protein Nkx-2.1 mAb

Datasheet

Background

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.


Gene Name

BCH, NKX2A, TITF1


Isotype

Mouse IgG


Predicted Mol Weight

38kDa


Reactivity

Human


Application

Source

This Abmart monoclonal antibody is produced by immunizing mice with a sythetic peptide(KLH coupled)corresponding to amino-terminal residues of human TTF-1


Storage

Store at -20°C, stable for one year from the date of shipment.


Recommanded Dilutions

Western blotting        1:1000-1:5000


M26007

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