病理Pathologic Biomarker-BCL6 mAb

Datasheet

Background

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.


Gene Name

BCL6

Isotype

Mouse IgG


Predicted Mol Weight

79 kDa


Reactivity

Human


Application

Source

This Abmart monoclonal antibody is produced by immunizing mice with a sythetic peptide(KLH coupled)corresponding to amino-terminal residues of human BCL6


Storage

Store at -20°C, stable for one year from the date of shipment.


Recommanded Dilutions

Western blotting        1:1000-1:5000


M26012

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