C1 INH (C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. Its main function is the inhibition of the complement system to prevent spontaneous activation. The protein is an acute-phase protein that circulates in blood at levels of around 0.25 g/L. The levels rise 2-fold during inflammation. C1 INH irreversibly binds to and inactivates C1r and C1s proteases in the C1 complex of classical pathway of complement. MASP-1 and MASP-2 proteases in MBL complexes of the lectin pathway are also inactivated. This way, it prevents the proteolytic cleavage of later complement components C4 and C2 by C1 and MBL. Although named after its complement inhibitory activity, the protein also inhibits proteases of the fibrinolytic, clotting, and kinin pathways. The protein is the most important physiological inhibitor of plasma kallikrein, fXIa, and fXIIa.

SERPING1, C1IN, C1NH

P05155

55kDa

This Abmart monoclonal antibody is produced by immunizing mice with a sythetic peptide(KLH coupled)corresponding to amino-terminal residues of

Mouse IgG

Homo sapiens

Store at -20°C, stable for one year from the date of shipment.

#M21001 Goat Anti-Mouse IgG-HRP
#M66001 Factor H Mouse mAb
#M66003 C1s Mouse mAb
#M66004 C1r Mouse mAb
#M66005 Properdin Mouse mAb
#M66006 Factor D Mouse mAb