膜蛋白-LRP1 Rabbit Antibody

Datasheet

Background

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.

Source

This Abmart monoclonal antibody is produced by immunizing mice with a polypeptide (Abmart SEAL mAb technology) corresponding to CD91 protein.

Protein Name

Prolow-density lipoprotein receptor-related protein 1

UniProt

Q07954

Alternative Names

LRP1, CD91

Application

Recommend Antibody Dilutions

Western blotting 1:500-1:1000
FACS 1:100-1:200

Molecular Weight

85kDa

Storage

Store at -20°C, stable for one year from the date of shipment.

Reactivity

Homo sapiens

Isotype

Rabbit IgG

T40021

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