膜蛋白-TNF-R2/TNFRSF1B Rabbit Antibody

Datasheet

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

Source

This Abmart monoclonal antibody is produced by immunizing mice with a polypeptide (Abmart SEAL mAb technology) corresponding to TNFRSF1B protein.

Protein Name

Tumor necrosis factor receptor superfamily member 1B

UniProt

P20333

Alternative Names

TNFRSF1B, CD120b, TBP-2, TBPII, TNFBR, TNFR2

Application

Recommend Antibody Dilutions

Western blotting 1:500-1:1000
FACS 1:100-1:200

Molecular Weight

48kDa

Storage

Store at -20°C, stable for one year from the date of shipment.

Reactivity

Homo sapiens

Isotype

Rabbit IgG

T40038

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