The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.

This Abmart monoclonal antibody is produced by immunizing mice with a polypeptide (Abmart SEAL mAb technology) corresponding to CD171 protein.

Neural cell adhesion molecule L1

P32004

L1CAM, CD171, CAML1, MIC5

Western blotting 1:500-1:1000
FACS 1:100-1:200

140kDa

Store at -20°C, stable for one year from the date of shipment.

Homo sapiens

Rabbit IgG