Cell Marker系列-SF3B1 Mouse Antibody

Datasheet

Background

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.


Gene Name

Hsh155, Prp10, PRPF10, SAP155, SF3b155, 155kDa; 2810001M05Rik; AA409119; Hsh155; MDS; PRP10; PRPF10; SAP155; SF3B1; SF3b155; TA-8; Targ4


Isotype

Mouse IgG


Predicted Molecular Weight

146 kDa


Reactivity

Human


Application

Source

This Abmart monoclonal antibody is produced by immunizing mice with a sythetic peptide(KLH coupled)corresponding to amino-terminal residues of human SF3B1


Storage

Store at -20°C, stable for one year from the date of shipment.


Recommend Antibody Dilutions

Western blotting        1:1000-1:5000                    
Immunoprecipitation     10 tests                
FACS                    1:100-1:200


Protein Alternative Names

Hsh155; MDS; pre-mRNA processing 10; pre-mRNA splicing factor SF3b, 155 kDa subunit; Pre-mRNA-splicing factor SF3b 155 kDa subunit; PRP10; PRPF10; SAP 155; SAP155; SF3b155; Spliceosome-associated protein 155; Splicing factor 3b; Splicing factor 3B subunit 1; splicing factor 3b, subunit 1, 155 kDa; splicing factor 3b, subunit 1, 155kDa; transforming growth factor alpha regulated gene 4

M25234

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