Cell Marker系列-MTA2 Mouse Antibody

Datasheet

Background

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

Source

This Abmart monoclonal antibody is produced by immunizing mice with a sythetic peptide(KLH coupled)corresponding to amino-terminal residues of human MTA2

Protein Name

MTA2

UniProt

O94776

Alternative Names

MTA1-L1,MTA1L1

Application

Recommend Antibody Dilutions

Western blotting        1:1000-1:5000                    
Immunoprecipitation     10 tests                
FACS                    1:100-1:200

Predicted Molecular Weight

75 kDa

Storage

Store at -20°C, stable for one year from the date of shipment.

Reactivity

Human

Isotype

Mouse IgG

M25055

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