Cell Marker系列-ACTIN1 Mouse Antibody

Datasheet

Background

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Source

This Abmart monoclonal antibody is produced by immunizing mice with a sythetic peptide(KLH coupled)corresponding to amino-terminal residues of human ACTN1

Protein Name

ACTN1

UniProt

P12814

Alternative Names

 Actinin; actinin 1 smooth muscle; actinin, alpha 1; alpha 1; alpha actinin 1a; alpha-actinin 1; Alpha-actinin cytoskeletal isoform; Alpha-actinin-1; F-actin cross-linking protein; FLJ40884; non-muscle alpha-actinin 1; Non-muscle alpha-actinin-1; 3110023F10Rik; ACTN1; Actn1a; BDPLT15; BOS_11045

Application

Recommend Antibody Dilutions

Western blotting        1:1000-1:5000                    
Immunoprecipitation     10 tests                
FACS                    1:100-1:200

Predicted Molecular Weight

103 kDa

Storage

Store at -20°C, stable for one year from the date of shipment.

Reactivity

Human

Isotype

Mouse IgG

M25063

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