High mobility group protein B1 encoded by the gene HMGB1 belongs to high mobility group and contains HMG-box domain. Like the histones, the protein is among the most important chromatin proteins. In the nucleus it interacts with nucleosomes, transcription factors, and histones. This nuclear protein organizes the DNA and regulates transcription. After binding, the protein bends DNA, which facilitates the binding of other proteins. The protein has been shown to play an important role in helping the RAG endonuclease form a paired complex during V(D)J recombination.

High mobility group protein B1

Amphoterin; Heparin-binding protein p30; high mobility group 1; High mobility group protein 1; High mobility group protein B1; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group box 1; HMG-1; HMG1; HMG3; SBP-1; Sulfoglucuronyl carbohydrate binding protein

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This Abmart monoclonal antibody is produced by immunizing mice with a polypeptide (Abmart SEAL mAb technology) corresponding to high mobility group protein B1 protein.

Mouse IgG

Pig

Western blotting                           1:1000-1:5000

Store at -20°C, stable for one year from the date of shipment.