Caspase 2 also known as CASP2 is an enzyme that, in humans, is encoded by the CASP2 gene. Caspase 2 proteolytically cleaves other proteins. It belongs to a family of cysteine proteases called caspases that cleave proteins only at an amino acid following an aspartic acid residue. Within this family, caspase 2 is part of the Ich-1 subfamily. It is one of the most conserved caspases in different species of animal. Caspase 2 has a similar amino acid sequence to initiator caspases, including caspase 1, caspase 4, caspase 5, and caspase 9. It is produced as a zymogen, which contains a long pro-domain that is similar to that of caspase 9 and contains a protein interaction domain known as a CARD domain. Pro-caspase-2 contains two subunits, p19 and p12.

Caspase-2

CASP-2, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, Protease ICH-1, ICH1, NEDD2

P42575

48,30,12kDa

This Abmart monoclonal antibody is produced by immunizing animals with a polypeptide (Abmart SEAL mAb technology) corresponding to Caspase-2 protein.

Rabbit IgG

Human Mouse Rat

WB 1:500~2000 IHC 50~200 ICC/IF 50~200

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.