Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that Survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. It also is a direct target gene of the Wnt pathway and is upregulated by beta-catenin.

Baculoviral IAP repeat-containing protein 5

Apoptosis inhibitor 4, Apoptosis inhibitor survivin, API4, IAP4

O15392

16kDa

This Abmart monoclonal antibody is produced by immunizing animals with a polypeptide (Abmart SEAL mAb technology) corresponding to Survivin protein.

Rabbit IgG

Human

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50 FC 1:50

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.