Voltage-dependent anion-selective channel 1 (VDAC-1) is a beta barrel protein that in humans is encoded by the VDAC1 gene. This protein is a voltage-dependent anion channel and shares high structural homology with the other VDAC isoforms (VDAC2 and VDAC3), which are involved in the regulation of cell metabolism, mitochondrial apoptosis, and spermatogenesis. Its Overexpression and misregulation could lead to apoptosis in the cell and a variety of diseases within the body. In particular, since VDAC1 is the major calcium ion transport channel, its dysfunction is implicated in cancer, Parkinson"s (PD), and Alzheimer"s disease.

Voltage-dependent anion-selective channel protein 1

VDAC-1, hVDAC1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM, VDAC

P21796

31kDa

This Abmart monoclonal antibody is produced by immunizing animals with a polypeptide (Abmart SEAL mAb technology) corresponding to VDAC1/Porin protein.

Rabbit IgG

Human Mouse Rat

WB 1:500~1:2000 IHC 1:50~1:200

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.