Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER . Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export . Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). .

Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) CALR CRTC

Mouse;Rat;Human

WB IHC IF

Western blotting: 0.2-2μg/mL;1:250-2500 Immunohistochemistry: 5-20μg/mL;1:25-100 Immunocytochemistry: 5-20μg/mL;1:25-100 Optimal working dilutions must be determined by end user.

49kD

CALR CRTC

P27797

Polyclonal

Signal transduction;Metabolic pathway;Bone metabolism;

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Liquid

500μg/mL

PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.