Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways . Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif . Binding generally results in the modulation of the activity of the binding partner . Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response . Also acts as a TP53/p53-regulated inhibitor of G2/M progression . When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis . May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 . .

14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) SFN HME1

Mouse;Rat;Human

WB IHC IF

Western blotting: 0.5-2μg/mL Immunocytochemistry in formalin fixed cells: 5-20μg/mL Immunohistochemistry in formalin fixed frozen section: 5-20μg/mL Immunohistochemistry in paraffin section: 5-20μg/mLOptimal working dilutions must be determined by end user.

28kD

SFN HME1

P31947

Polyclonal

Immune molecule;

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Liquid

500μg/mL

0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.