Gasdermin-D, N-terminal: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine. Homooligomerizes within the membrane and forms pores of 10 - 15 nanometers (nm) of inner diameter, possibly allowing the release of mature IL1B and triggering pyroptosis . Exhibits bactericidal activity. Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity.

Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT) (hGSDMD-NTD); Gasdermin-D, C-terminal (GSDMD-CT) (hGSDMD-CTD); Gasdermin-D, p13 (Gasdermin-D, 13 kDa) (13 kDa GSDMD); Gasdermin-D, p40]GSDMD DFNA5L GSDMDC1 FKSG10

Human,Mouse,Rat

WB,ICC,IHC-P,FC

WB:1:500-1:2,000;ICC:1:50-1:100;IHC-P:1:50-1:200;FC:1:50-1:100

53 kDa(pro), 35kDa(cleaved)

GSDMD DFNA5L GSDMDC1 FKSG10

SwissProt: P57764 Human;SwissProt: Q9D8T2 Mouse;SwissProt: Q9D8T2 Mouse

https://www.uniprot.org/uniprotkb/p57764

Rabbit

Polyclonal

Rabbit IgG

Cell Biology-gt;Other Antibodies-gt;Other Antibodies

SiHa cell lysates, human kidney tissue lysates, SiHa, rat stomach tissue, human tonsil tissue, human prostate carcinoma tissue, human esophagus tissue, Mouse colon tissue.

Protein affinity purified.

Liquid

1 mg/mL.

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.