The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO, and provides the primary link between glycolysis and the tricarboxylic acid cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase , dihydrolipoamide acetyltransferase and lipoamide dehydrogenase. The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) PDHA1 PHE1A

Human

WB,IP,FACS

Western blotting 1:1000-1:5000 Immunoprecipitation 10 tests FACS 1:100-1:200

43 KDa

PDHA1 PHE1A

P08559

https://www.uniprot.org/uniprotkb/p08559

This Abmart monoclonal antibody is produced by immunizing mice with a polypeptide (Abmart SEAL mAb technology) corresponding to ODPA protein.

Mouse

Monoclonal

Mouse IgG

Glucose metabolism #Tricarboxylic acid cycle

PBS, pH 7.4, 40% glycerol, and 0.01% sodium azide.

Store at -20°C, stable for one year from the date of shipment.