Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq]

Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) PPARA NR1C1 PPAR

Human, Mouse, Rat

IF, IHC, WB

WB 1:500, IHC 1:150, IF 1:100

52 kDa

PPARA NR1C1 PPAR

Q07869

https://www.uniprot.org/uniprotkb/q07869

Human recombinant protein fragment corresponding to amino acids 145-420 of human PPARA(NP_005027) produced in E.coli.

Mouse

Monoclonal

Mouse IgG

Nucleus localization

Differentiation #Fatty acid metabolism #Gluconeogenesis

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Liquid

1 mg/ml

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.