Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis.

Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4) BAX BCL2L4

Human Mouse Rat

WB,IHC,IP,FC

WB 1:1000~1:2000 IHC 1:50~1:200 IP 1:50 FC 1:50

21kDa

BCL2-associated X protein

Q07812

https://www.uniprot.org/uniprotkb/q07812

Rabbit

Monoclonal

Rabbit IgG

Apoptosis

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

AB_2910262