The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) DUSP4 MKP2 VH2

Human Mouse Rat

WB;IHC

WB 1:500-2000. IHC 1:50-150.

43kDa

1846

Q13115

https://www.uniprot.org/uniprotkb/Q13115

Recombinant protein of human DUSP4

Rabbit

Polyclonal

IgG

Affinity purification

Buffer: pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Store at -20℃. Avoid freeze / thaw cycles.