The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Interleukin-1 beta (IL-1 beta) (Catabolin) IL1B IL1F2

Human;Mouse;Rat

WB;IHC;IF

WB 1:2000-5000. IHC 1:25-100. IF 1:50-200.

31kDa

3553

P01584

https://www.uniprot.org/uniprotkb/P01584

Recombinant protein of human IL1B

1-269aa

Rabbit

Polyclonal

IgG

Cytoplasm

Apoptosis

Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20℃. Avoid freeze / thaw cycles.