High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFκB family, ATF-2 and c-Jun to activate transcription.

High mobility group protein B1 (High mobility group protein 1) (HMG-1) HMGB1 HMG1

Human Mouse Rat

WB,IHC,ICC/IF,FCM

WB 1:1000~1:2000 IHC 1:50~1:100 ICC/IF 1:50~1:100 FC 1:30

25kDa

HMGB1 HMG1

p09429

https://www.uniprot.org/uniprotkb/p09429

A synthesized peptide derived from human HMGB1

Rabbit

Monoclonal

Rabbit IgG

HMGB1 Antibody detects endogenous levels of total HMGB1

Autophagy #DNA recombination #Inflammatory response #Innate immunity #DNA recombination

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

AB_2937051