The tumor suppressor protein p21 Waf1/Cip1 acts as an inhibitor of cell cycle progression. It functions in stoichiometric relationships forming heterotrimeric complexes with cyclins and cyclin-dependent kinases. In association with CDK2 complexes, it serves to inhibit kinase activity and block progression through G1/S. However, p21 may also enhance assembly and activity in complexes of CDK4 or CDK6 and cyclin D.

Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1

Human

WB,IHC,ICC/IF,IP

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50

21kDa

CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1

p38936

https://www.uniprot.org/uniprotkb/p38936

A synthesized peptide derived from human p21

Rabbit

Monoclonal

Rabbit IgG

p21 Antibody detects endogenous levels of total p21

DNA damage

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.