CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development.

Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) MCAM MUC18

Human Mouse Rat

WB,IHC,ICC/IF,IP,FCM

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50 FC 1:50

72kDa

MCAM MUC18

p43121

https://www.uniprot.org/uniprotkb/p43121

A synthesized peptide derived from human CD146

Rabbit

Monoclonal

Rabbit IgG

CD146 Antibody detects endogenous levels of total CD146

Transmembrane

Angiogenesis #Cell adhesion #anatomical structure morphogenesis,

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.