Arrestin proteins function as negative regulators of G protein-coupled receptor (GPCR) signaling. Cognate ligand binding stimulates GPCR phosphorylation, which is followed by binding of arrestin to the phosphorylated GPCR and the eventual internalization of the receptor and desensitization of GPCR signaling. Four distinct mammalian arrestin proteins are known. Arrestin 1 (also known as S-arrestin) and arrestin 4 (X-arrestin) are localized to retinal rods and cones, respectively.

Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2) ARRB1 ARR1

Human Mouse Rat

WB,IHC,ICC/IF,FCM

WB 1:500~1:1000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:20

50kDa

ARRB1 ARR1

p49407

https://www.uniprot.org/uniprotkb/p49407

A synthesized peptide derived from human ARRB1

Rabbit

Monoclonal

Rabbit IgG

ARRB1 Antibody detects endogenous levels of total ARRB1

Protein transport

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.