Voltage-dependent anion channel (VDAC), ubiquitously expressed and located in the outer mitochondrial membrane, is generally thought to be the primary means by which metabolites diffuse in and out of the mitochondria. In addition, this channel plays a role in apoptotic signaling. The change in mitochondrial permeability characteristic of apoptosis is mediated by Bcl-2 family proteins, which bind to VDAC, altering the channel kinetics.

Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) VDAC1 VDAC

Human Mouse Rat

WB,IHC

WB 1:500~1:2000 IHC 1:50~1:200

31kDa

VDAC1 VDAC

p21796

https://www.uniprot.org/uniprotkb/p21796

A synthesized peptide derived from human VDAC1

Rabbit

Monoclonal

Rabbit IgG

VDAC1 Antibody detects endogenous levels of total VDAC1

Transmembrane

Apoptosis

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.