Pim1 a proto-oncogene serine/threonine kinase involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerced by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis.

Serine/threonine-protein kinase pim-1 (EC 2.7.11.1) PIM1

Human Mouse

WB,IHC,ICC/IF

WB 1:5000~1:10000 IHC 1:50~1:200 ICC/IF 1:50~1:200

32kDa

PIM1

p11309

https://www.uniprot.org/uniprotkb/p11309

A synthesized peptide derived from human PIM1

Rabbit

Monoclonal

Rabbit IgG

PIM1 Antibody detects endogenous levels of total PIM1

Apoptosis #Cell cycle

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.