经典一抗-PIM1 Antibody

Datasheet

Background

Pim1 a proto-oncogene serine/threonine kinase involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerced by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis.

Alternative Name

Serine/threonine-protein kinase pim-1 (EC 2.7.11.1) PIM1

Reactivity

Human Mouse

Predicted Reactivity

Application

WB,IHC,ICC/IF

Application Image

Recommanded Dilution

WB 1:5000~1:10000 IHC 1:50~1:200 ICC/IF 1:50~1:200

Mol Weight

32kDa

Gene Symbol

PIM1

Uniprot

p11309

Uniprot link

Immunogen

A synthesized peptide derived from human PIM1

Immunogen Range

Source

Rabbit

Clonality

Monoclonal

Isotype

Rabbit IgG

Specificity

PIM1 Antibody detects endogenous levels of total PIM1

Subcellular location

Research Area

Apoptosis #Cell cycle

Positive control

Conjugation

Modification

Purification

Affinity-chromatography

Formulation

Concentration

Buffer

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

产品介绍

Clone

Target

波长

Storage

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

注意事项

Companion Products

Important

Comments

RRID

客户评价

T55556

货号 规格 价格(¥)
T55556M 100μl
T55556S 50μl

以上产品均有现货供应

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

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技术支持:15618194176(微信同号)

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北方及西南经销商负责:手机13122150513(微信同号)

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微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13162017139(微信同号)

技术支持:15618194176(微信同号)

总机:021-34695901

南方经销商负责:手机13122837132(微信同号)          
北方及西南经销商负责:手机13122150513(微信同号)

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微信客服

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