Neurotrophins function to regulate naturally occurring cell death of neurons during development. The prototype neurotrophin is nerve growth factor (NGF), originally discovered in the 1950s as a soluble peptide promoting the survival of, and neurite outgrowth from, sympathetic ganglia. Three additional structurally homologous neurotrophic factors have been identified. These include brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) (also designated NT-5). These various neurotrophins stimulate the in vitro survival of distinct, but partially overlapping, populations of neurons.

Brain-derived neurotrophic factor (BDNF) (Abrineurin) [Cleaved into: BDNF precursor form (ProBDNF)] BDNF

Human Mouse Rat

WB,IHC,ICC/IF

WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

28kDa

BDNF

p23560

https://www.uniprot.org/uniprotkb/p23560

A synthesized peptide derived from human BDNF

Rabbit

Monoclonal

Rabbit IgG

BDNF Antibody detects endogenous levels of BDNF

Neurogenesis

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

AB_2936970