Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] ERN1 IRE1

Human

WB

WB 1:500~1:2000

110kDa

ERN1 IRE1

o75460

https://www.uniprot.org/uniprotkb/o75460

A synthesized peptide derived from human Phospho-IRE1 (S724)

Rabbit

Monoclonal

Rabbit IgG

Phospho-IRE1 (S724) Antibody detects endogenous levels of Phospho-IRE1 (S724)

Transmembrane

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.