Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] ERN1 IRE1
Human
WB
WB 1:500~1:2000
110kDa
ERN1 IRE1
o75460
A synthesized peptide derived from human Phospho-IRE1 (S724)
Rabbit
Monoclonal
Rabbit IgG
Phospho-IRE1 (S724) Antibody detects endogenous levels of Phospho-IRE1 (S724)
Transmembrane
Affinity-chromatography
PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。
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