Caspase-9 is an important member of the cysteine aspartic acid protease (caspase) family. Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).

Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] CASP9 MCH6

Human Mouse

WB,IHC,ICC/IF,IP

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50

46,39,37,35kDa

CASP9 MCH6

p55211

https://www.uniprot.org/uniprotkb/p55211

A synthesized peptide derived from human Caspase-9

Rabbit

Monoclonal

Rabbit IgG

Caspase-9 Antibody detects endogenous levels of Caspase-9

Apoptosis #DNA damage

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.