FoxO3a is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.

Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) FOXO3 FKHRL1 FOXO3A

Human Mouse Rat

WB,ICC/IF

WB 1:1000~1:2000 ICC/IF 1:50~1:200

90kDa

FOXO3 FKHRL1 FOXO3A

o43524

https://www.uniprot.org/uniprotkb/o43524

A synthesized peptide derived from human FoxO3a

Rabbit

Monoclonal

Rabbit IgG

FoxO3a Antibody detects endogenous levels of FoxO3a

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.