Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 CPP32

Human, Mouse, Rat

Pig,Sheep,Dog

WB,IHC,IF/ICC,ELISA

WB,IHC,IF/ICC, ELISA Recommended dilution WB 1:500-1:2000 IHC 1:50-1:500 IF/ICC 1:50-1:500 ELISA 1：2000

17kD; 32kDa(Calculated).

CASP3 CPP32

P42574

https://www.uniprot.org/uniprotkb/p42574

Rabbit

Polyclonal

Rabbit IgG

Cleaved-Caspase 3 (Asp175,p17) Antibody detects endogenous levels of fragment of activated Caspase 3 resulting from cleavage adjacent to Asp175.

Apoptosis #DNA damage

PBS,pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at -20 °C. Stable for 12 months from date of receipt.

AB_2936835