Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.(Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria.

Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] CDH1 CDHE UVO

Human, Mouse, Rat

Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog

WB,IHC,IF/ICC,ELISA

WB,IHC,IF/ICC, ELISA Recommended dilution WB 1:500-1:2000 IHC 1:50-1:500 IF/ICC 1:50-1:500 ELISA 1：2000

120kD; 97kDa(Calculated).

CDH1 CDHE UVO

P12830

https://www.uniprot.org/uniprotkb/p12830

Rabbit

Polyclonal

Rabbit IgG

E-cadherin Antibody detects endogenous levels of total E-cadherin.

PBS,pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at -20 °C. Stable for 12 months from date of receipt.

AB_2936787