Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.

Histone H2AX (H2a/x) (Histone H2A.X) H2AX H2AFX

Human Mouse Rat

WB,IHC,ICC/IF,IP

WB 1:5000~1:10000 IHC 1:50~1:200 ICC 1:50~1:200 IP 1:30

15kDa

H2AX H2AFX

p16104

https://www.uniprot.org/uniprotkb/p16104

A synthesized peptide derived from human Phospho-Histone H2A.X (S139)

Rabbit

Monoclonal

Rabbit IgG

Phospho-Histone H2A.X (S139) Antibody detects endogenous levels of total Phospho-Histone H2A.X (S139)

Nucleus localization

DNA damage #Meiosis #Spermatogenesis

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

AB_2936396