The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Toll-like receptor 4 (hToll) (CD antigen CD284) TLR4

Human;Mouse;Rat

Bovine;Pig;Cat;Horse;Nilgai;Chimpanzee;Gorilla;Bonobo

WB;IHC

WB 1:2000-5000. IHC 1:50-200.

73/91/96kDa

7099

O00206

https://www.uniprot.org/uniprotkb/O00206

Recombinant protein of human TLR4

8-334aa

Rabbit

Polyclonal

IgG

Cell membrane Cytoplasm

defense response to bacterium

Affinity purification

Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Store at -20℃. Avoid freeze / thaw cycles.