Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly.

Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]CASP1 IL1BC IL1BCE

Human, Mouse, Rat

WB,IF/IHC

WB1:1000-1:2000； IF/IHC 1:100-1:1000

20 kDa (cleaved p20); 35 kDa (cleaved p33); 45 kDa (pro caspase 1)

CASP1 IL1BC IL1BCE

P29466

Rabbit

Polyclonal

Rabbit IgG

Caspase 1 Antibody detects endogenous levels of total Caspase 1 and cleaved P20.

Apoptosis #Antiviral defense #defense response to bacterium

PBS, pH 7.4, 40% glycerol, and 0.01% sodium azide.

Store at -20 °C. Stable for 12 months from date of receipt.