Axin1 (Axis inhibition protein 1) and Axin2 are multidomain scaffold proteins that negatively regulate Wnt signaling. Axin1 interacts with APC, GSK-3β, Dvl, and β-catenin and promotes the GSK-3β-mediated phosphorylation and subsequent degradation of β-catenin .Down-regulates beta-catenin.

Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin) AXIN2

Human Mouse Rat

WB,IHC,ICC/IF

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

94kDa

AXIN2

q9y2t1

https://www.uniprot.org/uniprotkb/q9y2t1

A synthesized peptide derived from human Axin2

Rabbit

Monoclonal

Rabbit IgG

Axin2 Antibody detects endogenous levels of total Axin2

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.