Axin1 (Axis inhibition protein 1) and Axin2 are multidomain scaffold proteins that negatively regulate Wnt signaling. Axin1 interacts with APC, GSK-3β, Dvl, and β-catenin and promotes the GSK-3β-mediated phosphorylation and subsequent degradation of β-catenin .Down-regulates beta-catenin.
Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin) AXIN2
Human Mouse Rat
WB,IHC,ICC/IF
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200
94kDa
AXIN2
q9y2t1
A synthesized peptide derived from human Axin2
Rabbit
Monoclonal
Rabbit IgG
Axin2 Antibody detects endogenous levels of total Axin2
Affinity-chromatography
PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。
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